Pistorius bought, collected guns in Olympic year

In this photo taken Tuesday, Feb 26, 2012, participants take part in target practice at a shooting range in Krugersdorp, South Africa. In the light of the bail hearing for athlete Oscar Pistorius last week it came to light how police stumbled and fumbled through investigations. Police investigator Hilton Botha possibly contaminated the crime scene and faced attempted murder charges himself, placing even more strain on the credibility of the police. In recruiting personal the police have in a large way neglected the the quality of the personal recruited. It is in this lack of trust that guns thrive. (AP Photo/Cobus Bodenstein)

In this photo taken Tuesday, Feb 26, 2012, participants take part in target practice at a shooting range in Krugersdorp, South Africa. In the light of the bail hearing for athlete Oscar Pistorius last week it came to light how police stumbled and fumbled through investigations. Police investigator Hilton Botha possibly contaminated the crime scene and faced attempted murder charges himself, placing even more strain on the credibility of the police. In recruiting personal the police have in a large way neglected the the quality of the personal recruited. It is in this lack of trust that guns thrive. (AP Photo/Cobus Bodenstein)

FILE - In this Friday Feb. 22, 2013 file photo Olympic athlete, Oscar Pistorius, is watched by a policeman while in the dock during his bail hearing in Pretoria, South Africa, charged with the shooting death of his girlfriend, Reeva Steenkamp. During the hearing last week it was heard how police stumbled and fumbled through the bail hearing and how investigator, Hilton Botha, possibly contaminated the crime scene and faced attempted murder charges himself. (AP Photo, File)

JOHANNESBURG (AP) ? An official at a South African gun collectors' club where Oscar Pistorius was a member says he steadily became an avid collector of firearms in his Olympic year. He says Pistorius bought a collection of pistols and shotguns, all American manufactured, his favorite.

John Beare, vice chairman of the Lowveld Firearm Collectors Association, told The Associated Press that Pistorius also purchased a semi-automatic rifle for his expanding collection at the end of 2012.

That coincided with the early stages of Pistorius' romance with Reeva Steenkamp, the model he shot and killed at his home in the early hours of Feb. 14.

Prosecutors have charged Pistorius with premeditated murder for killing Steenkamp with three of four shots fired from his 9 mm pistol. Pistorius said he mistook Steenkamp for an intruder.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-01-OLY-Pistorius-Shooting-Gun-Collector/id-484227937d9d42a0854552ab6aa700b8

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Misplaced molecules: New insights into the causes of dementia

Mar. 1, 2013 ? A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the Proceedings of the National Academy of Sciences (PNAS).

ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS -- an average of 1 in 500 people.

Proteins gone astray

Over the last few years, there has been increasing evidence that ALS and FTD -- a form of dementia associated with changes in personality and social behaviour -- may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.

"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the disease."

Studies on zebrafish

However, until now little was known about the function of TDP-43. What are the consequences when this protein becomes non-functional? In order to answer this question, the team led by Bettina Schmid cooperated with the research group of Prof. Christian Haass to investigate the larvae of specially bred zebrafish. Their genetic code had been modified in such a way that no TDP-43 was produced in the organism of the fish. The result: the young fish showed massive muscle wasting and died a few days after hatching. Moreover, the extensions of the nerve cells which control the muscles were abnormal.

"To some extent, these are symptoms typical of ALS and FTD. Therefore, a loss of function of TDP-43 does seem to play a critical role in the disease," says Haass, Site Speaker of the DZNE Munich Site and chair of Metabolic Biochemistry at LMU.

The study revealed one more finding which surprised the researchers: the blood flow of the fish was massively disturbed. "It is well known that circulatory disorders play a part in other forms of dementia, notably in the case of Alzheimer's," says Haass. "We now want to investigate whether such problems with blood flow may be a general problem of neurodegenerative diseases and whether such problems occur particularly in patients with ALS and FTD."

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Story Source:

The above story is reprinted from materials provided by Helmholtz Association of German Research Centres, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. B. Schmid, A. Hruscha, S. Hogl, J. Banzhaf-Strathmann, K. Strecker, J. van der Zee, M. Teucke, S. Eimer, J. Hegermann, M. Kittelmann, E. Kremmer, M. Cruts, B. Solchenberger, L. Hasenkamp, F. van Bebber, C. Van Broeckhoven, D. Edbauer, S. F. Lichtenthaler, C. Haass. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1218311110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/1TV9qXbG57k/130302125402.htm

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5-year-old spends $2,500 in iPad app shopping spree

Your gadgets

Rosa Golijan TODAY

9 hours ago

We've heard plenty of stories about children who've managed to spend large sums of money on virtual items in mobile games without their parents' consent or knowledge, but one young boy's shopping spree made us raise our eyebrows nonetheless. The five-year-old racked up ?1,700 (about $2,500) in iTunes charges in a mere 15 minutes.

"Please, dad! It's a free app," Danny Kitchen pleaded with his father, Greg Kitchen, after the man refused to enter his iTunes password on an iPad to allow the boy to download a game, the BBC's Madeleine Ware reports. The cajoling eventually worked and the five-year-old was able to start playing his new game ... and purchase in-game items which would result in a real-world bill.

Yikes.

The Kitchen family got lucky. Apple will be refunding it for the in-game purchases (NBC News was able to confirm this), but that isn't the case for all parents. And the way some apps incorporate Apple's in-app purchase system doesn't exactly help prevent bills from piling up.

Apple has recently agreed to "settle a class action lawsuit that said customers were charged when their children inadvertently downloaded certain applications from the company's online store," a court filing provided to Reuters showed. Thanks to this proposed settlement, the Cupertino-based company may wind up paying out around $100 million in $5 iTunes store credits.

While most apps make it very clear that in-app purchases of points or in-app items ? such as crops or building material in a farm-themed game, weapons in an RPG, or currency in a virtual world ? do in fact cost real-world money, not all do. And occasionally, kids just plain might not comprehend that a few taps on a screen have the power to drain Mom and Dad's bank account.

Apple does offer "industry leading parental controls" in order to prevent accidental ? or simply unapproved ? in-app purchases, an Apple spokesperson said to NBC News. The settings in iOS allow parents to add password protection or to shut off in-app purchases entirely.

Shutting off in-app purchases entirely can be inconvenient to parents themselves, so odds are that most opt for the password protection option. Unfortunately that particular feature has a little flaw: Unless a parent changes the default setting, there is a 15-minute window after a password is entered during which someone can continue making purchases.

This small time window is what allowed Danny Kitchen to rack up $2,500 in charges.

Want more tech news or interesting links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on Twitter, subscribing to her Facebook posts, or circling her on Google+.

Source: http://www.today.com/tech/whoops-5-year-old-spends-2-500-15-minute-ipad-1C8644802

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Joke's on you, nerds! Obama troll quote is greatest 'Jedi mind meld' ever

Social media

Helen A.S. Popkin NBCNews.com

12 hours ago

The White House

An image posted by The White House Twitter account shortly after the Internet blew up over Obama's "Jedi mind meld" reference.

On Friday, President Barack Obama successfully distracted a tense nation from the mandatory spending cuts that are due to begin in mere hours through a sci-fi malapropism so egregious it caused the Twitterverse to explode ... metaphorically, anyway.

"I can't do a Jedi mind-meld to make Republicans do the right thing," Obama said in an impromptu press conference addressing the sequester deadline. Improperly combining the telepathic hypnosis techniques of two popular space-based franchises, the "Jedi mind trick" of Star Wars and the "Vulcan mind meld" of Star Trek, Obama caused nerds to feel the catastrophic disturbance in the Force.

It's the the social media equivalent of "crossing the streams," the thing Dr. Egon Spengler warned his fellow Ghostbusters never to do with their proton packs, for fear of a fairly serious setback:

"Try to imagine all life as you know it stopping instantaneously and every molecule in your body exploding at the speed of light."

Yet, as Dr. Ray Stanz's unfortunate conjuring of the Stay Puft Marshmallow Man necessitated, sometimes you have to cross streams. Or, in this case, mix up sci-fi references.

And so, to divert attention from the "fiscal cliff," the Reddit-savvy President fell back on an Internet meme made popular in 2010 ? he dropped a "troll quote."

It all started with a photo of Sir Ian McKellan's Gandalf accompanied by Yoda's quote "Do or do not, there is no try," and attributed to Harry Potter's Dumbledore. Infuriating, isn't it? Obama utters a seriously heinous troll quote, and now we can speak of little else. Whether it was initially on purpose or not, it's on now, especially after the White House released an image milking the trollery for all it's worth.

These are not the across-the-board federal budget cuts and harsh austerity measures you're looking for.

Helen A.S. Popkin goes blah blah blah about the Internet. Tell her to get a real job on Twitter and/or Facebook.

Source: http://www.today.com/tech/jokes-you-nerds-obama-troll-quote-greatest-jedi-mind-meld-1C8645122

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Google Launches Zopfli To Compress Data More Densely And Make Web Pages Load Faster

Google just launched Zopfli, a new open source compression algorithm that can compress web content about three to eight percent more densely (PDF) than the standard zlib library. Because Zopfli is compatible with the decompression algorithms that are already part of all modern web browser. Using Google's new algorithm and library on a server could lead to faster data transmission speeds and lower web page latencies, which would ultimately make the web a little bit faster.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/lsRvkMCPRsk/

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