Thursday, February 28, 2013

Protests mark anniversary of Trayvon Martin's shooting death

SANFORD, Fla./NEW YORK (Reuters) - Demonstrators symbolically wearing hoodies gathered in New York, Florida and California on Tuesday to mark the anniversary of the shooting death of unarmed black teenager Trayvon Martin, reviving a national discussion on gun laws and racial profiling.

Actor Jamie Foxx joined Martin's parents and several hundred protesters for a candlelight vigil in New York City's Union Square, while a smaller crowd estimated at 110 to 125 met at a park in the Florida town where Martin died, vowing to continue to agitate for an end to racial discrimination.

"We want you (to) know we love you and we won't leave you," Foxx told Martin's mother, Sybrina Fulton, in New York.

Neighborhood watch volunteer George Zimmerman shot and killed Martin, 17, in the Orlando suburb of Sanford on February 26, 2012, and initially went free based on his claims of self defense. Then a national outcry forced the city's police chief to resign and the governor to appoint a special prosecutor.

Zimmerman now faces second-degree murder charges and a June trial. He has maintained his innocence, and supporters say he has been unfairly tainted as racist, noting the neighborhood had been hit by a wave of break-ins and that Zimmerman is of mixed race - his father is white and his mother Afro-Peruvian.

In Sanford, the case triggered deep emotions, and protesters staged a candlelight vigil and moment of silence at 7:15 p.m., the time Martin was killed, at Fort Mellon Park.

"There are no excuses for violence against our children. Let us take the tragedy of Trayvon's death and use it for good," said organizer Geri Hepburn, a white parent of a teenage son who became politically active as a result of the shooting.

The crowd was small compared to the thousands who filled the same park at the apex of public outrage of the killing last year, when the story dominated national news for weeks.

SYMBOLIC HOODIES

In New York, demonstrators recreated the "Million Hoodie March" of last year, when people wore hooded sweatshirts in the style worn by Martin the night of his death, when Zimmerman called police to report a suspicious looking person in his gated neighborhood and defied a police admonishment not to follow him.

The coast-to-coast series of events also saw a crowd gather in the Leimert Park section of Los Angeles. Participants carried lit candles and many of them also wore hoodies, said organizer Najee Ali, who spoke at the gathering in Los Angeles.

"Trayvon was everyone's son. He belonged to all of us," Ali said in a phone interview.

Martin was on his way home to the house of his father's girlfriend, and the hoodie became a symbol of what critics considered racial profiling.

"We are all Trayvon Martin," demonstrators chanted at Tuesday's vigil.

James Flood, 33, a black bartender and screenwriter, said he was constantly the victim of racial profiling and wanted better for his 11-year-old son.

"My skin color cannot change no matter how much money I make. I still get profiled," Flood said. "It has to stop."

Zimmerman, 29, who was released on bail, remained out of sight on the anniversary.

Thrust into the national spotlight, Martin's grieving parents, Fulton and father Tracy Martin, have become national advocates for stricter gun control laws and critics of Florida's Stand Your Ground law.

The law, passed in 2005, allows people to use lethal force in self defense if they are in fear of serious bodily harm. More than 20 states have since passed similar laws.

Police cited that law in initially declining to arrest Zimmerman, which sparked celebrity protests and popular demonstrations across the country, turning the case into an international story.

Zimmerman's attorney plans to invoke the Stand Your Ground law at an April 29 hearing at which a Florida judge could determine if the law applied to Zimmerman, possibly granting him immunity and averting a criminal trial.

(Additional reporting by Alex Dobuzinskis in Los Angeles; Writing by Daniel Trotta; Editing by Steve Orlofsky, Cynthia Osterman and Lisa Shumaker)

Source: http://news.yahoo.com/protests-mark-anniversary-trayvon-martin-death-012438318.html

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Loss Of Online Privacy Kills Free Speech - Business Insider

A few months back, an advertising executive argued that more online privacy would kill free speech.

Richard Frankel, president of the advertising company Rocket Fuel, titled the post ?How the Do Not Track Plan Will Ultimately Kill Free Speech.?

It?s understandable that advertisers are so resistant to the concept of Do Not Track ? it could change the way they access data, which would force them to innovate their business models and practices.?

Just because DNT could impact the advertising industry in the short-term, however, doesn?t warrant its intense broadcasting of fear, uncertainty and doubt (FUD), and at times, outright deception. Frankels?s piece was one in a string of ad exec attacks on privacy that claim that the Internet will be doomed if consumers get more of the privacy they want.

In the interest of transparency, let me explain my angle here. I?m an attorney, privacy advocate, and analyst at Abine, an online privacy company in Boston. We make simple tools that give people a choice over whether their personal info is collected, stored, and sold online.

Unlike the advertising companies, we don?t collect or sell any user data. We only get paid if users like our free products and choose to buy our premium ones. It?s an up-front relationship that?s clear to our customers.

And beyond my role at Abine, I care deeply about preserving the web as a place where we can say and explore interesting, sometimes controversial, things. As a fan of free speech and expression, I have a vested interest in keeping the Internet open and uncensored.

Make no mistake about it: we live in a state of surveillance. Hundreds of advertising and tracking companies follow everything we do online -- the articles we read, the videos we watch, the sites we always visit, the Facebook comments we make, and more.

They combine that online data with offline data like our voting record, employment history, and marriage licenses, and use it to build an extremely detailed profile. Companies like Facebook scan the contents of photos and private messages for Homeland Security ?risk words? like ?infection,? ?body scanner,? or ?hacker? and turn them over to law enforcement.

Even if you delete your embarrassing Facebook posts, companies like Social Intelligence sell the past 7 years of posts to hiring managers. The wireless companies you pay for mobile service turn over 1.3 million customer records to law enforcement each year, which include texts and your phone?s GPS location wherever it went.

The divide between public and private surveillance is virtually nonexistent, and advertising companies are part of this ecosystem.

When you?re constantly being watched, you necessarily lack privacy. And when you?re constantly being watched, you act differently. That seems like an obvious point to those of us who?ve belted out song lyrics alone in our cars but would be terrified to do the same on stage in front of thousands or who laugh at things with their friends that they?d never say in front of their bosses, but observation effects are also well-established in scientific research, law, and popular culture (Big Brother, anyone?).

Privacy scholar Neil M. Richards writes that ?surveillance inclines us to the mainstream and the boring?when we are watched while engaging in intellectual activities, broadly defined?thinking, reading, web-surfing, or private communications?we are deterred from engaging in thoughts or deeds that others might find deviant.?

Deviance just means difference: deviation from the norm, creativity, standing out from the crowd. If you knew you were being watched and that your activities may resurface down the road in a job interview, on a date, in a newspaper, you?d be less likely to go that political rally, that Alcoholics Anonymous meeting, that gay bar, or that protest, all things that you have a right to do that are valued parts of a free, democratic society.

With privacy, you have control over who gets to see what you?re doing and where you are. You get to be one way around your boss, another around your kids, another around your best friends since elementary school. You get to pick that divide.

But when you?re watched all the time and you never know how that information will be used or where it?ll turn up, you censor yourself everywhere. This is called the Panopticon Effect. All this openness that social networks insist we want by default, the pervasive data collection that advertisers argue is good for us: they make anyone who?s paying attention censor themselves.

A key part of free speech is anonymous speech. Anonymous speech is a constitutionally protected First Amendment right, and as the Supreme Court stated in McIntyre v. Ohio Elections Commission, ?an honorable tradition of advocacy and of dissent.?

Online advertising constantly fights against anonymity and pseudonymity, trying to learn everything about web users to unmask them and peel away layers of demographic info, interests, and behaviors. Many social networks like Facebook have real name policies, insisting that members use their full, legal names on their accounts or be banned.

Frankel says that ?With higher ad revenues comes more rich content that spurs vibrant discussion.? I disagree. You know what spurs vibrant discussion? People, especially people behind pseudonyms. Ever been on a message board? A Reddit thread?

The most ?vibrant? discussions happen when people feel sufficiently protected to be honest. Sure, some people hide behind pseudonyms to harass others, but the core of the First Amendment avoids censoring the positive, protected uses of speech just because certain bad actors may abuse it.

To say that advertising is the only thing driving creative content doesn?t give credit to humanity?s ingrained creativity. First, plenty of content providers get paid for their work directly, from recording artists to bestselling authors to journalists. 43% of Americans pay content creators?authors of magazine articles and books?for e-books, and there are 400,000 paid subscribers to the Wall Street Journal alone.

The majority of people blogging and posting on social media today create content out of a desire to express themselves that?s unrelated to money. Just talk to any one of the thousands of bloggers and podcasters, particularly the anonymous ones, who pay to host their own websites just to get their message out to the public.

Most of these people don?t blog or podcast for a living; they do it because they love it and because their message is important to them. There?s power?and satisfaction?in speaking one?s mind, and it exists independently from ad money.

Privacy isn?t a hindrance to free speech; it?s the driving force behind it. Privacy provides both the boundaries of and protection for the space in which we can be ourselves. Privacy nurtures self-expression, creativity, speaking your mind, associating with whomever you wish, and exploring your interests.?

These are the First Amendment?s protections:? freedom of speech, of association, and of assembly.? They?re so important for self-actualization and self-determination that our founders immortalized them in the Bill of Rights. Privacy isn?t about having something to hide; it?s about having something to live for.

Why the ad industry is wrong about Do Not Track

A few months back, an advertising executive argued that more online privacy would kill free speech. Richard Frankel, president of the advertising company Rocket Fuel, titled the post ?How the Do Not Track Plan Will Ultimately Kill Free Speech.?

It?s understandable that advertisers are so resistant to the concept of Do Not Track ? it could change the way they access data, which would force them to innovate their business models and practices.? Just because DNT could impact the advertising industry in the short-term, however, doesn?t warrant its intense broadcasting of fear, uncertainty and doubt (FUD), and at times, outright deception.

Frankels?s piece was one in an ongoing string of ad exec attacks on privacy that claim that the Internet will be doomed if consumers get more of the privacy they want.

In the interest of transparency, let me explain my angle here. I?m an attorney, privacy advocate, and analyst at Abine, an online privacy company in Boston. We make simple tools that give people a choice over whether their personal info is collected, stored, and sold online. Unlike the advertising companies, we don?t collect or sell any user data.

We only get paid if users like our free products and choose to buy our premium ones. It?s an up-front relationship that?s clear to our customers. And beyond my role at Abine, I care deeply about preserving the web as a place where we can say and explore interesting, sometimes controversial, things.

As a fan of free speech and expression, I have a vested interest in keeping the Internet open and uncensored.

Make no mistake about it: we live in a state of surveillance. Hundreds of advertising and tracking companies follow everything we do online -- the articles we read, the videos we watch, the sites we always visit, the Facebook comments we make, and more.

They combine that online data with offline data like our voting record, employment history, and marriage licenses, and use it to build an extremely detailed profile. The divide between public and private surveillance is virtually nonexistent, and advertising companies are part of this ecosystem.

In this post, I?ll address Frankel?s argument - and the other advertisers using similar arguments - which goes something like this: 1) behavioral (or tracking-based) advertising is how online advertisers make money; 2) without advertising, content providers like online newspapers won?t be able to survive; 3) with paid subscriptions; only rich people who can afford content will get it, creating class segmentation.

In brief, here?s why they?re wrong:

1) the majority of online advertising revenue comes from contextual ads, which don?t pose any personal privacy risks;
2), the online advertising industry?s move to real-time bidding platforms are actually hurting content providers far more than a shift from behavioral advertising to contextual advertising ever could; and
3), beyond this being a reductio ad absurdum argument (?everything will be locked behind a paywall if we stop tracking!?), this segmentation already exists through the filter bubble that the advertising industry and its tracking has caused.

Realistically, online privacy isn?t going to hurt anything but these advertisers? antiquated business models, which will have to adapt to respect the privacy of their target audiences.

Let?s first examine the fallacy that online tracking doesn?t use personal information. Frankel argues that ?Targeted, relevant ads don?t harm consumers?personal information is not necessary, or collected, to produce them.?

This statement is less than fully honest when we look at Rocket Fuel?s own website, which boasts that it can ?zero in on? people based on ?age, gender, profession, ethnicity, and relationship status,? among many other personal characteristics. They have more than 20,000 audience segments, including soccer moms and caregivers:

The company goes on to say that they can find ?users engaged in highly targeted activities that define their interests and personalities? by going ?beyond behavioral, contextual, or geo-targeting by combining intelligent demographic, lifestyle, purchase-intent, and social data with our own suite of targeting algorithms, blended analytics, and expert analysis.?

And they?re not just using your online activity here:? ?Online data has evolved from simply providing insights like browsing activity, shopping cart info, sign ups, etc. into an incredible selection of more than 20,000 unique audience segments. Advertisers can even leverage offline purchase and consumption data for their online campaigns.?

Obviously, significant amounts of personal information are being collected. And the traditional advertiser counter-argument that ?it?s not personally identifiable; it?s only aggregate info? has been debunked time and time again by researchers like Stanford?s Arvind Narayanan and Jonathan Mayer (also see privacy professor Paul Ohm?s excellent summary of the failure of anonymization) and publications like the Wall Street Journal, which found in a December 2012 study that nearly 25% of the web?s 70 most popular sites shared personal data, like name and email address, with third-party companies.

Ad companies like Mixpanel come right out and say ?Now you can tie any kind of data to your users to see exactly who they are and what they have done.? The myth that de-identified data is private is even weaker now with the rise of ?data enhancement? that matches online info with offline data sets.

The only reason these ads can be personalized is because of the personal information, the data collection, that powers them. That?s the real harm here, and that?s always been the harm, despite advertisers trying to shift the focus to targeted ads. No one cares about targeted ads: at worst, they?re annoying or creepy. Let?s just drop it.

The thing people don?t like is having their personal info harvested, mined, sold, and used in ways they can?t even imagine: for determining their credit limits or creditworthiness, playing into whether they get a job, showing them different prices than other people see for the same online shopping items, or influencing their insurance rates.

Even Frankel seems to doubt himself: he says that ?consumers have become more open to [ads],? and then contradicts himself 6 paragraphs later when he says ?Everyone claims to hate online advertising.? His second statement is more accurate: an October 2012 UC Berkeley study found that most people--69%--never or hardly ever find ads useful, and 85% never or hardly ever click them; and a 2012 Pew phone survey of 2,253 participants found that 68% of them were ?not okay with targeted advertising because [they] don?t like having [their] online behavior tracked and analyzed.?

Microsoft surveyed their users about privacy in 2012 and found that 83% of Americans, 84% of Germans, and 81% of UK residents think that ?tracking of personal information is out of hand and consumers need easier ways to block it.? I won?t keep going; you get the picture. The advertising industry keeps preaching about how great data collection is for all of us. If the benefits are so clear, then why not let consumers choose to enable it? Overwhelmingly, the opposite is happening.

Let?s fact-check some of Frankel?s, and the advertising industry in general?s, more unsubstantiated statements:

Online ads have become ?less invasive?

If by ?invasive? he means ?in your face? like pop-ups, then he?s right. But just because data collection is invisible doesn?t mean it?s somehow safer or less intrusive. Advertisers employ a massive array of secret tracking techniques, collecting far more personal information than ever before in history, and they haven?t had the best rap while doing it: remember KISSmetrics creating undeletable cookies?

Google circumventing privacy controls in Safari and getting a $22.5 million FTC fine? Ad network Chitika?s opt-out that only lasted 10 days in contrast to any reasonable consumer?s expectations? Facebook tracking logged-out users anywhere there?s a Like button on the web?

Online tracking is only getting worse: UC Berkeley?s Web Privacy Census, powered by Abine?s privacy software, found an alarming increase in tracking on the top US websites, showing that online tracking will double in 2.5 years if present trends continue.

?The alternative to an ad-supported Internet is a pay-for-play world supported by subscriptions or private ownership. Consumers may think they want an ad-free Internet, but do we really want to pay subscription fees to access all the sites we currently visit for free??

Frankel wrongly equates ?behavioral advertising? with ?all advertising? and offers a false choice between an ad-supported Internet and an all-paid subscription Internet. He neglects to mention that the vast majority of advertising revenue comes from contextual ads, ads that relate to the content the viewer sees and not the personal characteristics of the viewer.

Contextual ads don?t present a privacy problem, and they make up the majority of online advertisements. The reality is that privacy controls will not have a negative impact on the economics of the Internet (at least not past this short-term period of transition), as I?ve argued elsewhere.

And it?s not as though advertisers are truthfully concerned about publishers? bottom lines. Significant evidence suggests the opposite: although online advertising is getting cheaper for advertisers, it?s getting more costly for publishers.

In the past, publishers had the power when pricing ads. You wanted a full-page New York Times ad? There?s a set price for that. With the recent advent of real-time online bidding platforms, advertisers hurt content providers by competing more effectively and cutting down the content provider?s take and involvement.

And at bottom, there?s plenty of research showing that plenty of people will pay small price increases for more privacy. A few dollars is all that?s needed to make the difference, so we?re not talking about a prohibitive expense. Offer people a choice: those who don?t mind surrendering their privacy can keep the status quo, but people who want to avoid it can throw in a few bucks to do so.

The Do Not Track option could serve as the dividing line to signal a consumer?s choice about privacy. Of course, it would need to live up to consumer expectations and actually stop tracking on websites, which notable websites like Twitter have done.

Do Not Track would ?reduc[e] the effectiveness of advertising?

To the contrary. Do Not Track has great potential to increase the effectiveness of advertising. Why? Because Do Not Track lets people tell advertisers not to use certain personalized ads that they find ineffective, usually because they find them creepy or annoying.

Do Not Track is a clear communication from web users to advertisers about which ads those users prefer; which ads work better for them. If ads annoy people and make them build negative associates with the things advertised, they?re not effective advertising.

Even with Do Not Track, advertisers still get to collect and sell user data for advertising: they just can?t show personalized online ads. According to the definition of Do Not Track offered by advertisers (which is at odds with what real people want), people who don?t want to be tracked will still see ads, but not personalized ones. Meanwhile, all other web users will keep seeing behaviorally targeted ads.

Across the board?regardless of whether a consumer clicked Do Not Track?advertisers will still collect all consumers? personal data exactly as before. Again, their definition, not ours.? This definition means that consumers get to voice which type of ads they prefer?personalized or not?and advertisers can still collect and sell everyone?s info. It?s a win-win for advertisers, far from the end of the Internet economy and a blow to advertising effectiveness.

?If independent publishers lose a large percentage of their ad revenues because Do Not Track or other initiatives restrict the free flow of information on the web, they?ll have less money to fund unbiased, journalistic content creation?

We already have a restricted flow of free information on the web, thanks to advertising. Ever heard of a filter bubble? It?s ?a situation in which a website algorithm selectively guesses what information a user would like to see based on information about the user (such as location, past click behavior and search history) and, as a result, users become separated from information that disagrees with their viewpoints, effectively isolating them in their own cultural or ideological bubbles.?

In other words, the more that advertisers or websites (or both, in the case of sites like Google and Facebook) know about you, the more they envelop you with targeted content. You don?t see the same Google search results as everyone else, or the same Amazon home page. Even news sites are targeted to show you articles they think you?ll like. Personal data collection fuels filter bubbles.

Frankel says that greater privacy will ?muffle the voices of many consumers who can?t or won?t pay to express their opinions.? You know what muffles voices? Surveillance, tracking, and the threat that what you say today will be used against you in the future.

That?s why anonymous speech is constitutionally protected and why many people choose to mask themselves when they make political comments. Online advertising works extremely hard to unmask those people, identify them, sell their data, and barrage them with ads. And that?s not what people want.

Source: http://www.businessinsider.com/loss-of-online-privacy-kills-free-speech-2013-2

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New cars increasingly out of reach for many

Looking to buy a new car, truck or crossover? You may find it more difficult to stretch the household budget than you expected, according to a new study that finds median-income families in only one major U.S. city actually can afford the typical new vehicle.

The typical new vehicle is now more expensive than ever, averaging $30,550 in 2012, according to TrueCar.com data, and heading up again as makers curb the incentives that helped make their products more affordable during the recession when they were desperate for sales.

According to the 2013 Car Affordability Study by Interest.com, only in Washington, D.C., could the typical household swing the payments, the median income there running $86,680 a year. At the other extreme, Tampa was at the bottom of the 25 large cities included in the study, with a median household income of $43,832.

The study looked at a variety of household expenses, such as food and housing, and when it comes to purchasing a new vehicle, it considered more than just the basic purchase price, down payment and monthly note, factoring in such essentials as taxes and insurance.

Bottom line? A buyer in the capital can purchase a car with a sticker price of $31,940, slightly more than the new vehicle average for the 2013 model year and about what it would cost for a mid-range Ford Fusion sedan or a stripped-down BMW X1 crossover. The buyer in Tampa? They?ll just barely cover the cost of a basic Kia Rio, with $14,516 to spend.

More from The Detroit Bureau: Hyundai settles lawsuit for false mileage claims

?If you live in New York City or San Francisco, you?re probably going to have to pay a lot for housing, but you don?t have to pay a lot for a car,? said Mike Sante, the managing editor of Interest.com, a financial decision-making website.

Affordability has been a matter of growing concern for the auto industry in recent years as prices have continued to move upward. Even the most basic of today?s cars are generally loaded with features that were once found on high-line models a few decades back ? if they were available at all ? such as air conditioning, power windows, airbags and electronic stability control, as well as digital infotainment systems. They also have to meet ever tougher federal safety, emissions and mileage standards that have added thousands to the typical price tag.

?The average compact car of today has the features of a midsize model somebody might be trading in ? but it may be just as expensive,? said David Sargent, director of automotive operations for J.D. Power and Associates.

That is one reason why many buyers have been downsizing in recent years, said Bill Fay, general manager of Toyota, though he added that ?there is still a lot of affordability in the marketplace.?

Perhaps, but industry planners have come to recognize that they are targeting a much smaller segment of the American public than in decades past. That?s one reason why most manufacturers are offering more downsized models.

More from The Detroit Bureau: Consumer Reports names its 'Top Picks'

They also are working with their dealers to offer certified pre-owned programs where buyers can stretch their budget by purchasing a two- or three-year-old vehicle that has gone through an extensive inspection and, if necessary, repairs and replacements. Such vehicles may cost slightly more than a conventional used model but usually include a like-new warranty.

While the typical new vehicle will likely nudge up this year, Interest.com editor Sante stressed that car costs are one of the most controllable parts of a household?s budget. ?You?re better off driving something more affordable and saving or investing the difference.?

If the typical new car costs $30,550, with an average monthly payment of $550, the five cities most able to meet ? or come close ? are:

1) Washington, D.C.
Average Household Income: $86,680
Affordable Purchase Price: $31,940
Maximum monthly payment: $628

2) San Francisco
Average Household Income: $71,975
Affordable Purchase Price: $26,786
Maximum monthly payment: $537

3) Boston
Average Household Income: $69.455
Affordable Purchase Price: $26,025
Maximum monthly payment: $507

4) Baltimore
Average Household Income: $65,463
Affordable Purchase Price: $24,079
Maximum monthly payment: $468

5) Minneapolis
Average Household Income: $63,352
Affordable Purchase Price: $24,042
Maximum monthly payment: $470

At the other end of the scale, those five cities least able to handle a car payment are:

21) Phoenix
Average Household Income: $50,058
Affordable Purchase Price: $17,243
Maximum monthly payment: $348

22) San Antonio
Average Household Income: $48,699
Affordable Purchase Price: $17,137
Maximum monthly payment: $334

23) Detroit
Average Household Income: $48,968
Affordable Purchase Price: $17,093
Maximum monthly payment: $332

24) Miami
Average Household Income: $45,407
Affordable Purchase Price: $15,188
Maximum monthly payment: $295

25) Tampa
Average Household Income: $43,832
Affordable Purchase Price: $14,516
Maximum monthly payment: $282

More from The Detroit Bureau

Copyright ? 2009-2013, The Detroit Bureau

Source: http://www.nbcnews.com/business/new-cars-increasingly-out-reach-many-americans-1C8573730

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Long-term use of medication does not improve symptoms for heart failure patients

Feb. 26, 2013 ? Among patients with heart failure with preserved ejection fraction, long-term treatment with the medication spironolactone improved left ventricular diastolic function but did not affect maximal exercise capacity, patient symptoms, or quality of life, according to a study appearing in the February 27 issue of JAMA.

"Heart failure (HF) with preserved ejection fraction [EF; the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat is 50 percent or greater] accounts for more than 50 percent of the total HF population," according to background information in the article. There is not an established therapy for this condition, and aldosterone (a hormone) stimulation may contribute to its progression.

Frank Edelmann, M.D., of the University of Gottingen, Germany, and colleagues conducted a study to examine the long-term effects of spironolactone, an aldosterone receptor blocker, on diastolic function and exercise capacity in patients with HF with preserved EF. The Aldo-DHF trial, a randomized, placebo-controlled trial, was conducted between March 2007 and April 2012 at 10 sites in Germany and Austria. The study included 422 patients (average age, 67 years) with chronic New York Heart Association class II or III heart failure, preserved left ventricular ejection fraction of 50 percent or greater, and evidence of diastolic dysfunction. Patients were randomly assigned to receive 25 mg of spironolactone once daily (n = 213) or matching placebo (n = 209) with 12 months of follow-up. The primary outcomes measured were changes in diastolic function (E/e') on echocardiography and maximal exercise capacity (peak VO2) on cardiopulmonary exercise testing.

The researchers found that spironolactone improved some measures (left ventricular end-diastolic filling, left ventricular remodeling, and neurohumoral activation). Maximal exercise capacity did not significantly change with spironolactone vs. placebo, and spironolactone did not improve heart failure symptoms or quality of life and slightly reduced 6-minute walking distance. "Spironolactone also modestly increased serum potassium levels and decreased estimated glomerular filtration rate without affecting hospitalizations."

The authors conclude that the "lack of accepted minimal clinically important differences in E/e' or peak VO2 in HF with preserved EF warrants additional prospective, randomized, adequately powered studies to further evaluate the effect of improving diastolic function on symptomatic, functional, and clinical end points."

Editorial: Defining Diastolic Heart Failure and Identifying Effective Therapies

"Ultimately, Aldo-DHF trial provides valuable new information but is not particularly reassuring in terms of either the efficacy or safety of mineralocorticoid antagonists (MRAs) for patients with heart failure with preserved ejection fraction (HFpEF),"writes John G. F. Cleland, M.D., Ph.D., F.R.C.P., and Pierpaolo Pellicori, M.D., of the University of Hull, Kingston-upon-Hull, England, in an accompanying editorial.

"In the meantime, MRAs appear useful for managing congestion and preventing diuretic-induced hypokalemia [abnormally low level of potassium in the circulating blood] with the attendant risk of sudden arrhythmic death. It is likely that these benefits are independent of cardiac phenotype but might be more prominent in those with impaired aldosterone degradation due to hepatic congestion. Whether MRAs exert important benefits for patients with HFpEF through other mechanisms such as reducing fibrosis, inflammation, and adrenergic activity may take longer to unravel."

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The above story is reprinted from materials provided by American Medical Association (AMA).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Frank Edelmann et al. Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection FractionThe Aldo-DHF Randomized Controlled Trial. JAMA, 2013 DOI: 10.1001/jama.2013.905

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/CPq_J5Fjdoo/130226162725.htm

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New study shows viruses can have immune systems

New study shows viruses can have immune systems [ Back to EurekAlert! ] Public release date: 27-Feb-2013
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Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences Campus

A pirate phage commandeers the immune system of bacteria

BOSTON (February 27, 2013, embargoed until 1 p.m. US ET) A study published today in the journal Nature reports that a viral predator of the cholera bacteria has stolen the functional immune system of bacteria and is using it against its bacterial host. The study provides the first evidence that this type of virus, the bacteriophage ("phage" for short), can acquire a wholly functional and adaptive immune system.

The phage used the stolen immune system to disable and thus overcome the cholera bacteria's defense system against phages. Therefore, the phage can kill the cholera bacteria and multiply to produce more phage offspring, which can then kill more cholera bacteria. The study has dramatic implications for phage therapy, which is the use of phages to treat bacterial diseases. Developing phage therapy is particularly important because some bacteria, called superbugs, are resistant to most or all current antibiotics.

Until now, scientists thought phages existed only as primitive particles of DNA or RNA and therefore lacked the sophistication of an adaptive immune system, which is a system that can respond rapidly to a nearly infinite variety of new challenges. Phages are viruses that prey exclusively on bacteria and each phage is parasitically mated to a specific type of bacteria. This study focused on a phage that attacks Vibrio cholerae, the bacterium responsible for cholera epidemics in humans.

Howard Hughes Medical Institute investigator Andrew Camilli, Ph.D., of Tufts University School of Medicine led the research team responsible for the surprising discovery.

First author Kimberley D. Seed, Ph.D., a postdoctoral fellow in Camilli's lab, was analyzing DNA sequences of phages taken from stool samples from patients with cholera in Bangladesh when she identified genes for a functional immune system previously found only in some bacteria (and most Archaea, a separate domain of single-celled microorganisms).

To verify the findings, the researchers used phage lacking the adaptive immune system to infect a new strain of cholera bacteria that is naturally resistant to the phage. The phage were unable to adapt to and kill the cholera strain. They next infected the same strain of cholera bacteria with phage harboring the immune system, and observed that the phage rapidly adapted and thus gained the ability to kill the cholera bacteria. This work demonstrates that the immune system harbored by the phage is fully functional and adaptive.

"Virtually all bacteria can be infected by phages. About half of the world's known bacteria have this adaptive immune system, called CRISPR/Cas, which is used primarily to provide immunity against phages. Although this immune system was commandeered by the phage, its origin remains unknown because the cholera bacterium itself currently lacks this system. What is really remarkable is that the immune system is being used by the phage to adapt to and overcome the defense systems of the cholera bacteria. Finding a CRISPR/Cas system in a phage shows that there is gene flow between the phage and bacteria even for something as large and complex as the genes for an adaptive immune system," said Seed.

"The study lends credence to the controversial idea that viruses are living creatures, and bolsters the possibility of using phage therapy to treat bacterial infections, especially those that are resistant to antibiotic treatment," said Camilli, professor of Molecular Biology & Microbiology at Tufts University School of Medicine and member of the Molecular Microbiology program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University.

Camilli's previous research established that phages are highly prevalent in stool samples from patients with cholera, implying that phage therapy is happening naturally and could be made more effective. In addition, a study published by Camilli in 2008 determined that phage therapy works in a mouse model of cholera intestinal infection.

The team is currently working on a study to understand precisely how the phage immune system disables the defense systems of the cholera bacteria. This new knowledge will be important for understanding whether the phage's immune system could overcome newly acquired or evolved phage defense systems of the cholera bacteria, and thus has implications for designing an effective and stable phage therapy to combat cholera.

###

Additional authors are David W. Lazinski, Ph.D., senior research associate in the Camilli lab at Tufts University School of Medicine, and Stephen B. Calderwood, M.D., Morton N. Swartz, M.D. academy professor of medicine at Harvard Medical School, and chief, division of infectious disease and vice-chair, department of medicine at Massachusetts General Hospital.

Research reported in this publication was supported by the National Institute of Allergies and Infectious Diseases of the National Institutes of Health under award numbers R01AI55058, R01AI045746, and R01AI058935.

Seed, K.D., Lazinski, D.W., Calderwood, S.B., and Camilli, A. (2013). A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity. Nature, vol 494, issue 7438, pp 489 DOI: 10.1038/nature11927

About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences

Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.

If you are a member of the media interested in learning more about this topic, or speaking with a faculty member at the Tufts University School of Medicine or another Tufts health sciences researcher, please contact Siobhan Gallagher at 617-636-6586 or siobhan.gallagher@tufts.edu.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New study shows viruses can have immune systems [ Back to EurekAlert! ] Public release date: 27-Feb-2013
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Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-636-6586
Tufts University, Health Sciences Campus

A pirate phage commandeers the immune system of bacteria

BOSTON (February 27, 2013, embargoed until 1 p.m. US ET) A study published today in the journal Nature reports that a viral predator of the cholera bacteria has stolen the functional immune system of bacteria and is using it against its bacterial host. The study provides the first evidence that this type of virus, the bacteriophage ("phage" for short), can acquire a wholly functional and adaptive immune system.

The phage used the stolen immune system to disable and thus overcome the cholera bacteria's defense system against phages. Therefore, the phage can kill the cholera bacteria and multiply to produce more phage offspring, which can then kill more cholera bacteria. The study has dramatic implications for phage therapy, which is the use of phages to treat bacterial diseases. Developing phage therapy is particularly important because some bacteria, called superbugs, are resistant to most or all current antibiotics.

Until now, scientists thought phages existed only as primitive particles of DNA or RNA and therefore lacked the sophistication of an adaptive immune system, which is a system that can respond rapidly to a nearly infinite variety of new challenges. Phages are viruses that prey exclusively on bacteria and each phage is parasitically mated to a specific type of bacteria. This study focused on a phage that attacks Vibrio cholerae, the bacterium responsible for cholera epidemics in humans.

Howard Hughes Medical Institute investigator Andrew Camilli, Ph.D., of Tufts University School of Medicine led the research team responsible for the surprising discovery.

First author Kimberley D. Seed, Ph.D., a postdoctoral fellow in Camilli's lab, was analyzing DNA sequences of phages taken from stool samples from patients with cholera in Bangladesh when she identified genes for a functional immune system previously found only in some bacteria (and most Archaea, a separate domain of single-celled microorganisms).

To verify the findings, the researchers used phage lacking the adaptive immune system to infect a new strain of cholera bacteria that is naturally resistant to the phage. The phage were unable to adapt to and kill the cholera strain. They next infected the same strain of cholera bacteria with phage harboring the immune system, and observed that the phage rapidly adapted and thus gained the ability to kill the cholera bacteria. This work demonstrates that the immune system harbored by the phage is fully functional and adaptive.

"Virtually all bacteria can be infected by phages. About half of the world's known bacteria have this adaptive immune system, called CRISPR/Cas, which is used primarily to provide immunity against phages. Although this immune system was commandeered by the phage, its origin remains unknown because the cholera bacterium itself currently lacks this system. What is really remarkable is that the immune system is being used by the phage to adapt to and overcome the defense systems of the cholera bacteria. Finding a CRISPR/Cas system in a phage shows that there is gene flow between the phage and bacteria even for something as large and complex as the genes for an adaptive immune system," said Seed.

"The study lends credence to the controversial idea that viruses are living creatures, and bolsters the possibility of using phage therapy to treat bacterial infections, especially those that are resistant to antibiotic treatment," said Camilli, professor of Molecular Biology & Microbiology at Tufts University School of Medicine and member of the Molecular Microbiology program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University.

Camilli's previous research established that phages are highly prevalent in stool samples from patients with cholera, implying that phage therapy is happening naturally and could be made more effective. In addition, a study published by Camilli in 2008 determined that phage therapy works in a mouse model of cholera intestinal infection.

The team is currently working on a study to understand precisely how the phage immune system disables the defense systems of the cholera bacteria. This new knowledge will be important for understanding whether the phage's immune system could overcome newly acquired or evolved phage defense systems of the cholera bacteria, and thus has implications for designing an effective and stable phage therapy to combat cholera.

###

Additional authors are David W. Lazinski, Ph.D., senior research associate in the Camilli lab at Tufts University School of Medicine, and Stephen B. Calderwood, M.D., Morton N. Swartz, M.D. academy professor of medicine at Harvard Medical School, and chief, division of infectious disease and vice-chair, department of medicine at Massachusetts General Hospital.

Research reported in this publication was supported by the National Institute of Allergies and Infectious Diseases of the National Institutes of Health under award numbers R01AI55058, R01AI045746, and R01AI058935.

Seed, K.D., Lazinski, D.W., Calderwood, S.B., and Camilli, A. (2013). A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity. Nature, vol 494, issue 7438, pp 489 DOI: 10.1038/nature11927

About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences

Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical education and advanced research. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, biomedical sciences, special combined degree programs in business, health management, public health, bioengineering and international relations, as well as basic and clinical research at the cellular and molecular level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical science.

If you are a member of the media interested in learning more about this topic, or speaking with a faculty member at the Tufts University School of Medicine or another Tufts health sciences researcher, please contact Siobhan Gallagher at 617-636-6586 or siobhan.gallagher@tufts.edu.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/tuhs-nss022513.php

Daily Show provisional ballot

Plan your vacation at the planned city of La Plata - TRAVEL and ...

Also known as the City of Diagonals because of its many diagonal roads, La Plata is an ideal example of a planned metropolis. La Plata is the capital of the Buenos Aires province and is located only 56 km from the capital. The well planned city has many great public buildings and several green areas. In fact, there is a green area every seven blocks of the city, wherever you go. The planning of La Plata gives it a surreal feeling as any portion of the city looks similar to the tourist, thus giving an impression of moving in the crossroads of a gigantic puzzle.


Weather in La Plata
Weather in La Plata is mild. It is best defined as a humid subtropical climate. Winters can be very cold and the temperature can reach below freezing point. However, snowfall is rare in La Plata. The average high temperature of the place reaches about 21 degree Celsius and the average low temperature is around 11 degrees. La Plata has an average humidity of about 77 % owing to its coastal location.

Tourist Places La Plata
Among the tourist places La Plata is the Natural History Museum which is a highlighted tourist attraction of the city. The museum consists of many dinosaur skeletons, some of them extraordinarily huge and artifacts from the pre Columbian traditions of South America. The metropolitan Cathedral and the Palacio municipal are two other famous tourist spots in La Plata. There are many other tourist places La Plata like the Iglesia San Benjamin, the Curutchet house, the Casa Mariani, plus many others.

Accommodation in La Plata
Several options for accommodation in La Plata are there. There are hotels ranging from budget hotels to the posh ones. Inns and Bread n Breakfast accommodation are also available at La Plata. Thus, finding accommodation in La Plata would not be a problem.

Places to Eat in La Plata
There are several places to eat in La Plata. From authentic Argentinean cuisines to Italian to Japanese to Mexican and to Mediterranean cuisines, you will find cuisines from every part of the world in this city. If you just want pizza, you can visit the Loco Ponte. For Argentinean cuisine, you should make it a point to visit the Thionis, the Don Quixote and the El Retiro. The Durango presents an international palate to visitors and the Jesolo is well known for the Italian cuisine. You can even find Japanese food at Akari Sushi.
Things to Do in La Plata
Among things to do in La Plata includes travelling around the city. As every part of the city has a green park, travelling throughout the city is a great experience.? You can go to many restaurants located at different parts of the city. Further, the clubs and discotheques situated around the city center region are worth visiting. Joguru Team Praveen is a prominent and amateur writer, primarily focusing on providing La Plata Travel Guide for those planning to travel to La Plata. Here you can get relevant facts about tourist places in La Plata, weather, nightlife, things to do, accommodation, places to eat in La Plata and lots more.

Source: http://travelleisure99.blogspot.com/2013/02/plan-your-vacation-at-planned-city-of.html

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CSN: Bochy pulls son after substandard outing

SCOTTSDALE, Ariz. ? Bruce Bochy?s son might have a locker in the Giants? major league camp, but don?t accuse the manager of nepotism.?

It?s usually not considered a favor to bring a relief pitcher into a bases-loaded, one-out situation.

That?s what the Giants? manager did Monday, calling on his son, Brett, in the eighth inning. The 25-year-old right-hander made a couple of nervous location mistakes in his first Cactus League appearance this spring while giving up a double and a home run to a pair of White Sox minor leaguers.

The Giants once led 9-0 but Seth Loman?s three-run home run tied the score, and the game ended in a 9-9 tie.

?I put him in a tough spot, but he?s a tough kid,? the elder Bochy said. ?He?ll be fine. ? The first time out ? for these young kids, I don?t pay any attention to it.?

A visit from pitching coach Dave Righetti helped to calm down Brett Bochy, who was the closer at Double-A Richmond last year and uses movement and deception to miss bats. He got a strikeout and a ground ball to end the inning and preserve the tie.

?That?s a tough spot, but you?ve got to be ready for that when you pitch late in games,? Brett Bochy said. ?I?m nervous every time out and there?s definitely more the first time.?

Neither father nor son did anything out of the ordinary when the elder Bochy walked to the mound and handed over the baseball. The manager said the previous pitcher, Fabio Castillo, had reached his pitch limit and Brett was the next name on the list.

?Being the first time, I noticed him,? Brett said. ?But once I toed the rubber it?s like any other game.?

--

The pitching wasn?t very good after Sergio Romo threw his inning, as Chris Heston gave up two runs before Castillo began to melt down. All the positives came much earlier in the game on the offensive side.

Andres Torres, playing his first game in a Giants uniform since 2011, lined an RBI single to left field and alertly took second base on the throw home. Torres came out after two at-bats because he?s had a bit of oblique soreness and just began taking swings again from the left side in batting practice earlier Monday. He batted right-handed twice in the game before the White Sox switched to a right-handed pitcher.

Bruce Bochy said Torres should be fine with a bit more rest.

--

Hector Sanchez (sore shoulder) threw to bases with no issues Monday and is likely to begin catching in games in another two to three days, Bruce Bochy said.

--

Bruce Bochy still expects Matt Cain to make his next start on Thursday. Cain walked through the clubhouse with no apparent limp a day after he took an Alfonso Soriano line drive off the side of his right knee.?

--

The sight of Hunter Pence frenetically legging out a triple never gets old. Pablo Sandoval continues to look locked in, too. He smoked a double to center field. And Cole Gillespie doubled twice. It's only a couple games, as Bruce Bochy reminded us, but he does like what he's seen thus far from the non-roster outfielder.

--

The Giants had a chance to win in the bottom of the ninth, but Angel Villalona grounded into a double play with runners at first and second to end it.

--

No, Buster Posey is not perfect. He dropped a foul pop just a few feet behind home plate. Of course, that?s a bit easier to forgive when he?s standing on a logo that says, ?2012 WORLD CHAMPIONS.??

Source: http://www.csnbayarea.com/blog/andrew-baggarly/extra-baggs-bochys-son-has-rough-outing-etc

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Samsung Wallet Is Apple's Passbook, on Android

Samsung has just announced its new Wallet mobile payment app at the Mobile World Congress and... and it looks a hell of a lot like Apple's Passbook. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/7NUFYBTujdY/samsung-wallet-is-apples-passbook-on-android

TD Bank mountain lion

Wednesday, February 27, 2013

US, allies planning direct aid to Syrian rebels

Jacquelyn Martin / AP

Secretary of State John Kerry, left, shakes hands after a news conference with French Minister of Foreign Affairs Laurent Fabius at the Foreign Ministry in Paris on Wednesday.

By Andrea Mitchell and Catherine Chomiak, NBC News

In a policy shift, the United States on Thursday will announce plans to channel aid directly to selected groups of the Syrian opposition rather than through non-governmental agencies, senior White House officials told NBC News.

The aid plan, being?forged with European allies, will still not include weapons, despite the calls of a growing number of American senators?? but the definition of "non-lethal" aid will be more broadly defined, the officials said, noting that details of the plan were still being finalized.


Secretary of State John Kerry, who is in Paris on his first foreign trip in his new position,?said earlier that?Washington is looking for new ways to help rebels fighting the government of Syrian President Bashar Assad and speed up political transition in the country.

"We are examining and developing ways to accelerate the transition the Syrian people seek and deserve," Kerry said during a news conference with French Foreign Minister Laurent Fabius.

The Washington Post?has reported that?the administration was planning to start sending non-lethal equipment like body armor and armed vehicles to Assad's foes.

Among the items likely to be included in the direct aid to rebels are meals and medical kits, The Associated Press reported.

Kerry was expected to announce the new contributions at the Rome conference, in addition to tens of millions of dollars intended for rule of law and governance programs.

For its part, the Syrian opposition is planning to demand "qualitative military support" at talks with major powers in Rome this week, a leading figure in movement to oust Assad told Reuters on Wednesday.

"We ask our friends to give us every backing to achieve gains on the ground and help reach a political solution from a position of strength, not weakness," said Riad Seif of the Syrian National Coalition umbrella group said a day before a Friends of Syria conference in the Italian capital.

"We expect to receive political, humanitarian and qualitative military support,? he said.

The Friends of Syria group is composed mainly of Western powers, Gulf Arab states opposed to the Iranian-backed Assad, and Turkey.

The West and Syria's neighbors have been looking for a solution to the two-year-old civil war in Syria that has claimed around 70,000 lives and sent 860,000 refugees fleeing abroad. The conflict pitting the largely Sunni rebels against the Alawite-dominated Assad?government?threatens to destabilize countries in the region, most notably Lebanon.

In Paris, Kerry said the United States wanted the Syrian opposition's advice on how to accelerate a political solution to help halt the bloodshed and protect the interests of the Syrian people.

"We want (the Syrian opposition's) advice on how we can accelerate the prospects of a political solution because that is what we believe is the best path to peace, the best way to protect the interest of the Syrian people," he said ahead of meetings with the opposition on Thursday.

During his first overseas trip as secretary of state, John Kerry hinted at a policy shift saying that Syrian opposition isn't going to be 'dangling in the wind wondering where the support is.' NBC's Andrea Mitchell reports.

"As I have said, that may require us to change President al-Assad's current calculation. He needs to know that he can't shoot his way out of this. So we need to convince him of that and I think the opposition needs more help in order to be able to do that. And we are working together to have a united position," Kerry added.?

But Iraq's prime minister warned that a victory for the rebels in Syria would create new problems, by creating a haven for extremists and worsening sectarian tensions in the Middle East.

In an interview with the AP, Nouri al-Maliki stopped shy of expressing support for the Assad regime.

The prime minister's remarks reflect fears by many Shiite Muslims in Iraq and elsewhere that Sunni Muslims would come to dominate Syria should Assad be toppled.

"If the world does not agree to support a peaceful solution through dialogue ... then I see no light at the end of the tunnel," al-Maliki said.

"Neither the opposition nor the regime can finish each other off," he continued. "The most dangerous thing in this process is that if the opposition is victorious, there will be a civil war in Lebanon, divisions in Jordan and a sectarian war in Iraq."

As the bloody Syrian conflict wears on, there is a growing number of U.S. legislators urging greater action, including some type of military support for the rebels.

Sen. Roger Wicker, a member of the Armed Services Committee, appearing on NBC's Andrea Mitchell Reports on Wednesday.

"I hope our new secretary of state will listen carefully to the more responsible of the Syrian opposition," said Wicker, a member of the Senate Armed Services Committee.

Asked if that meant the United States should provide weapons, he said: "I think there are ways and means for us to see that is done. I think Secretary of State Kerry is going to be listening to those proposals, and I think if he does what he's being told at the highest levels of the Pentagon, we may be moving, yes, to military aid for the responsible opposition groups."

He agreed that there is a risk to those weapons falling into the hands of radical extremists infiltrating the opposition movement, but said.

"There's no question it's a concern, but this has gone on too long. The Assad regime needs to fall."

Andrea Mitchell is NBC News chief foreign affairs correspondent. Catherine Chomiak is an NBC News producer. Reuters and The Associated Press contributed to this report.

Related:

Huge blast rocks central Damascus as Assad hints at talks

In initial coup for Kerry, Syria's opposition to attend Rome meeting

Dozens killed after huge car bomb hits Syria's capital

Source: http://worldnews.nbcnews.com/_news/2013/02/27/17118363-us-allies-planning-direct-aid-to-syrian-rebels?lite

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Wireless connections creep into everyday things

In this Tuesday, Feb. 26, 2013, photo, a woman sits on an eCooltra Connected electric scooters at the Mobile World Congress, the world's largest mobile phone trade show, in Barcelona, Spain. The first wave of the wireless revolution was getting people to talk to each other through cellphones. The second, it seems, will be getting things to talk to each other, with no human intervention: cars that talk to your insurance company?s computers, bathroom scales that talk to your phone, and electric meters that talk to your air conditioners. So-called machine-to-machine technology all the buzz at this year?s largest wireless trade show, and some analysts believe these types of connection will outgrow the traditional phone business in less than a decade. (AP Photo/Manu Fernandez)

In this Tuesday, Feb. 26, 2013, photo, a woman sits on an eCooltra Connected electric scooters at the Mobile World Congress, the world's largest mobile phone trade show, in Barcelona, Spain. The first wave of the wireless revolution was getting people to talk to each other through cellphones. The second, it seems, will be getting things to talk to each other, with no human intervention: cars that talk to your insurance company?s computers, bathroom scales that talk to your phone, and electric meters that talk to your air conditioners. So-called machine-to-machine technology all the buzz at this year?s largest wireless trade show, and some analysts believe these types of connection will outgrow the traditional phone business in less than a decade. (AP Photo/Manu Fernandez)

(AP) ? A car that tells your insurance company how you're driving. A bathroom scale that lets you chart your weight on the Web. And a meter that warns your air conditioner when electricity gets more expensive.

Welcome to the next phase of the wireless revolution.

The first wave of wireless was all about getting people to talk to each other on cellphones. The second will be getting things to talk to each other, with no humans in between. So-called machine-to-machine communication is getting a lot of buzz at this year's wireless trade show. Some experts believe these connections will outgrow the traditional phone business in less than a decade.

"I see a whole set of industries, from energy to cars to health to logistics and transportation, being totally redesigned," said Vittorio Colao, the CEO of Vodafone Group PLC, in a keynote speech at the Mobile World Congress in Barcelona, Spain. The British cellphone company has vast international interests, including its 45 percent ownership stake in Verizon Wireless.

Companies are promising that machine-to-machine, or M2M, technology will deliver all manner of services, from the prosaic to the world-changing. At U.S. chipmaker Qualcomm Inc.'s booth here at the show, there's a coffeepot that can be ordered to start brewing from a tablet computer, or an Internet-connected alarm clock. A former president of Costa Rica is also at the show, talking about how M2M can save massive amounts of greenhouse gases by making energy use more efficient ? enough to bring mankind halfway to the goal of halting global warming.

The M2M phenomenon is part of the larger drive to create an "Internet of Things" ?a global network that not only links computers, tablets and phones but that connects everything from bikes to washing machines to thermostats. Machina Research, a British firm, believes there will be 12.5 billion "smart" connected devices, excluding phones, PCs and tablets, in the world in 2020, up from 1.3 billion today.

But how does this transformation happen, and who stands to profit?

First, the devices have to be able to connect. That's not a trivial undertaking, especially considering that people don't upgrade washing machines or renovate their homes as often as they change cellphones and PCs. One company at the show, a Los Angeles-based startup named Tethercell, has an ingenious solution for battery-powered devices: a "fake" AA battery that houses a smaller AAA battery in an electronic jacket. It can be placed in a battery compartment with other batteries. Within a distance of 80 feet, some smartphones and tablets can then signal the "battery" to turn the device on or off. For instance, parents whose kids have a lot of noisy toys can turn all of them off with touch of a single button. A fire alarm could send a text-message warning that its battery is running low, rather than blaring an audio signal.

Unfortunately, a Tethercell from the first production run costs $35. Co-founder Kellan O'Connor believes the price can come down to $10, but that's still a non-trivial cost, and symptomatic of the high price of building out the Internet of Everything. For devices that need to connect at long range over a cellular network, the cost of radio components alone ranges from $10 to $70, according to analyst Dan Shey of ABI Research.

That's not expensive in the context of some big-ticket items, like cars, which have been forerunners when it comes to non-phone wireless connections. General Motors Corp. started equipping cars with OnStar wireless calling and assistance services in the mid-90s. At the show, it announced it is updating the service for faster data connections, enabling services like remote engine diagnostics and upgrades to the control software. AT&T Inc., which has been aggressive about getting into the M2M business, is ousting Verizon Wireless as the network provider for OnStar.

Colao, the CEO of Vodafone, gave an example of another "smart" car application that might seem intrusive to some: the company has been trying out a service in Italy that lets an auto insurance company know how much a car is being used, and charges premiums accordingly. It can also score the driver based on his or her driving style, and give pointers on how to handle the car more safely.

Cellular connections are creeping into smaller, cheaper devices. Ecooltra, which rents out electric scooters by the day in Spain, wants to connect them to the Internet, which would let renters figure out through their phones where there's a scooter for rent and how much of a charge is in its battery. The feature is perfect for quick, impromptu rentals by the hour. Adding "smarts" to the scooters in the shape of a cellular modem would turn the company from a conventional rental service to a "scooter-sharing" business, much like car-sharing services like Zipcar.

Once devices are connected, the next problem is getting them to talk to each other, and making sense of what they're saying. ABI's Shey says this is the real business opportunity in M2M, more valuable than making the modems or providing the wireless connections. He believes that's driving a behind-the-scenes scramble of deal-making at the show, as companies like AT&T seek to bolster their ability to support M2M by acquiring companies that provide a "middle layer" of software between the devices and their owners.

For connections between devices in the home, like that remote-controlled coffee-pot, Qualcomm touts its AllJoyn project, which it seeks to make an industry standard. Currently, the main ways for devices to connect to each other and figure out what they can do, like Bluetooth and DLNA, are too limited and difficult to use, said Rob Chandhok, president of Qualcomm Innovation Center.

With AllJoyn, "there's nothing to stop you from making a speaker that listens for notifications and turns them into speech, so you hear, 'Hey, you left the refrigerator door open!'" Chandhok said. "You take very simple things and connect them, and people build experiences on top of them. That's what we're trying to do."

Jose Maria Figueres, the former president of Costa Rica, is now the president of the Carbon War Room, an organization co-founded by billionaire Richard Branson to promote cutbacks in greenhouse-gas emissions through smart private enterprise. Figueres believes M2M has huge potential to wring efficiency out of energy-guzzling activities, and could reduce emissions equivalent to 9.1 billion tons of carbon dioxide by 2020 ? roughly equal to the combined emissions of India and the U.S. today.

Vodafone provided one example of how this might be done. The city of Groningen in the Netherlands has put sensors in the trash containers that serve public-housing units. They alert trash haulers when they need to be emptied, saving on unnecessary trips and reducing fuel use by 18 percent.

With M2M, "in many cases you have information moving instead of us moving," Figueres said.

In another example, Dutch authorities started controlling their street lights wirelessly rather than with "dumb" timers. They save on energy by dimming the lights if traffic is scant, but can also turn them on early if the day is dark.

Could M2M be overhyped ? a promise that won't deliver? The wireless industry is no stranger to rosy projections that don't pan out. Shey, the ABI analyst, thinks M2M will deliver, but perhaps not in a sexy, flashy way. When machine-to-machine connections are created, he said, it's usually not because someone is making a big bet on the future, but because they save money.

"It's about gaining more out of the asset that you have, like a truck. When it needs maintenance it gets maintenance at the right point. Or ensuring that the vending-machine guy only goes to the vending machine when it's empty," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-02-27-Wireless%20Show-Internet%20of%20Everything/id-7dab9ca2d8a441efbedc8c3cb7b53470

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You'll Be Able to Download Every Single PS4 Game Digitally

Though we're still waiting to see what the PS4 is going to look like, we definitely have a handle on the guts and how the next gen system will work. And that includes downloading PS4 games digitally. According to Sony exec Shuhei Yoshida, every single PS4 game will be available to download online. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/vYUIuXH_sqQ/youll-be-able-to-download-every-single-ps4-game-digitally

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Orbitz Flights, Hotels, Cars (for iPad)


As a comprehensive travel searching and booking service, Orbitz has traditionally been my first stop online anytime I need to investigate the cost of a car rental, explore the best possible dates to take a summer holiday, or find a last-minute flight during a family emergency. On the iPad, however, Orbitz is only just now catching up to its competitors, finally extending its Orbitz Flights, Hotels, Cars iPhone app to the full sized tablet. (Previously, Orbitz's only dedicated iPad app offered search and booking for hotel rooms only.) Officially called Orbitz Flights, Hotels, Cars (free), the app centralizes your ability to search for and pay upfront for reservations in all three categories invoked in the name. The app works quickly and fairly well, but not with quite as much finesse and fun as Kayak PRO iPad app (99 cents, 4.5 stars), our Editors' Choice among travel search and booking apps on the iPad, and the competitor that Orbitz should watch most closely.

Orbitz's app is more than fine?and similar to Kayak's in many ways?but a few interface choices and lack of features make it pale slightly in comparison. For example, the Orbitz iPad app doesn't let you explore places to travel based on the best price you can find all year long, as Kayak's iPad app does. Nor can you find the status of a flight that you need to track as easily as you can on Kayak's app. The one major advantage to using Orbitz is the company's price assurance, which isn't specific to the iPad at all.

Searching and Booking Flights, Hotels, Cars
Orbitz's iPad app pits the trinity of travel search across the top of the screen with three main icons for hotels, flights, and car rentals. While on the full Orbitz website you can search for all three reservations in one fell swoop, they're kept separate in the iPad app. Kayak similarly keeps the searches separate, although it displays the options along the left rail, which results in a slightly cleaner and simpler design, in my opinion.

You can jump among the three sections easily enough, and, when you do, Orbitz remembers your most previous dates and cities, and it auto-fills them into the search criteria.

The flight search appears to support one-way, round-trip, and multi-city journeys, although that last one is a farce. Click the multi-city option, and Orbitz will tell you to go to its full website instead. Kayak's iPad app, meanwhile, fully supports multi-city journeys. Two other options from the primary flight search area let you select the number of travelers (and say whether they are adults, children, infants, etc.) and choose between economy, business, and first class fares.

The search results appear quickly, with a left panel showing a running list of flight option summaries, with filters and sorting tools accessible at the top. The main area of the screen, however, doesn't fill in until you select one of the possibilities. That blank area doesn't exactly draw you into the possibilities. When you do tap a summary to see more details, the use of space again feels very unbalanced, and the resulting information, when affiliated with a round-trip search, doesn't even show all the information?it only gives you the outbound details. The reason: Orbitz lets you choose your outbound and inbound legs separately, which on the one hand gives you more flexibility in deciding exactly the flights you want, but on the other hand can drastically change the price you initially saw in the summary based on which return flight you choose.

Once you have your flights picked, you're only one tap away from a payment page, which gets the app back on track to being a convenient and efficient tool for travelers.

Two more sections, a flight tracker and "my trips" section, which shows upcoming travel when you're logged in with an Orbitz account, give the app even more utility, although the flight tracker needs to be more search-friendly. You can only search by airline and flight number, whereas often, people only know the time of the flight and departure/arrival cities. Kayak's app has the additional search options, as well as the ability to save flight-tracking for multiple flights, which is especially helpful for frequent travelers or small business owners who need to watch the status of multiple employees' flights.

The hotel section and results page work much in the same manner as the flights, with appropriate filters to help you narrow down your options. One filter called "areas" puts a much more user-friendly spin on the "distance" filter found in Kayak. Orbitz lets you choose by neighborhood name or district, which makes sense if you're perhaps looking for a hotel in Oakland, California, but need to be near the UC Berkeley campus (just choose "Berkeley, Emeryville").

Hotel photos, ratings, and amenities are all easy to find in Orbitz's app. An interactive map likewise makes it simple to see where a hotel is situated. Neither Orbitz nor Kayak includes in its hotel search results alternative accommodations, such as private house rentals or apartment for let on a daily or weekly basis. For those options, try Hipmunk iPad app (free, 3.5 stars), which also has some really interesting filter options for hotels, like proximity to nightlife and being in a pedestrian-friendly area.

Searching for car rentals in Orbitz's iPad is straightforward, too, and one helpful feature is how it displays comparisons from one select provider. Select any search results, and a preview window shows additional cars from the company, such as mid-sized sedan or SUV, and how much extra it will cost to get that option. In this context, seeing not the total price but how much more makes sense.

Oddities and Lack of Extras
One area where Orbitz could really improve its iPad app would be to add some additional exploratory features, something that gives armchair travelers a reason to launch it. Currently, the app is very utilitarian, whereas Kayak includes an entire section dedicated solely to exploring cheap flights anywhere around the world from any starting destination. Given that Orbitz's full website includes loads of other travel ideas and deals, like vacation packages and cruises, Orbitz could and should leverage that content in the app to make it more fun. It would play well to the platform's surfing and entertainment uses, to be sure.

Orbitz is clearly still new to the tablet app space and needs to clean up the experience a little bit. Some of its most basic functionality and layout choices just seem off. For example, what appears to be a "profile" button (the silhouette of a head and shoulders) turns out to be a logout button.

Choose Orbitz for its Additional Services, Not for its App Design
Orbitz's strength remains its ability to help you not only search for, but also pay for, flights, hotel stays, and rental cars. And its price assurance policy is the second leg that keeps Orbitz upright. While Kayak has been adding the ability to pay for bookings as of late, it traditionally was just a search site, and thus doesn't have a reputation for providing a soup-to-nuts experience, which Orbitz does. Customer reputation goes a long way in the travel industry.

If you're an Orbitz customer and time permits, work through your search criteria on Kayak before buying on Orbitz. Chances are the reservation will be offered from Orbitz via Kayak, which means you have nothing to lose and everything to gain by starting on Kayak, our Editors' Choice for iPad travel search and booking apps.

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Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/bgBwQmwAUdM/0,2817,2415865,00.asp

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